The double-layer glass reaction kettle is designed with double-layer glass, and the inner layer can be filled with reaction solvent for stirring reaction. The interlayer can be connected with different cold and heat sources (frozen liquid, hot water or hot oil) for high-temperature reaction (equipped with corresponding circulating oil bath, with a high temperature of up to 250 ℃) or low-temperature reaction (equipped with corresponding low-temperature frozen liquid circulation system, with a low temperature of up to -80 ℃), or a heating and cooling integrated cycle machine can be selected; Under constant temperature conditions, in a sealed glass reactor, stirring reactions can be carried out under normal or negative pressure conditions according to usage requirements, and the reaction solution can be refluxed and distilled. During use, vacuum can be pumped to perform vacuum reactions. It is an ideal pilot and production equipment for modern fine chemical, biopharmaceutical, and new material synthesis. Its unique design makes the experiment safer and more convenient.